KCS

N-methyl tetrazole moiety has known one of the biological component. In the known procedure for the synthesis of 2-methyl tetrazole, the ratio range of N2/N1-methyl phenyl tetrazole is form 1:1 to 4:1 by reaction with MeI or dimethyl sulfate in polar aprotic solvent under various basic conditions. Methyl salicylate is a mild methylation agent for the esterification of carboxylic acids by hydrogen bonds effect between the hydroxyl groups. When we applied methyl salicylate as a methylation reagent for a synthesis of 5-phenyl-2-methyl-2H-tetrazole with functional groups, the ratio of N2/N1-methyl phenyl tetrazole is more than 6:1. We will introduce reaction conditions and scope for a synthesis of 2-alkyl tetrazoles.