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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Self-Assembled Amphiphlic Graft Poly(organophosphazene) Micellar Host with Hydrophobic Guest

등록일
2015년 2월 26일 16시 28분 15초
접수번호
1499
발표코드
MAT.P-1184 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
김명훈, 최진호1,*
서울대학교 바이오엔지니어링 협동과정, Korea
1이화여자대학교 화학.나노과학과, Korea
A facile soft chemical route to resveratrol-polyphosphazene micelle (RSV-PPZ) was demonstrated on the basis of guest molecule mediated self-assembly. We synthesized a new type of amphiphlic graft PPZ ([NP(MPEG550)1.5(GlyPheLeuEt)0.5]n) modulated by varying the balance of hydrophilicity and hydrophobicity to induce tunable morphology in a micellar structure. RSV, the highly hydrophobic polyphenolic compound, was encapsulated with newly designed PPZ by hydrophobic-hydrophobic interaction. RSV medicated PPZ micelles were stable in very low critical micelle concentrations (~20 mg/l) with spherical morphology and average size 14 nm of RSV-PPZ. And an attempt was also tried to understand an effect of micelle structure of RSV-PPZ on solubility enhancement and reducing toxicity. Therefore, we can conclude hydrophobic guest molecule mediated micelle could be a potential candidate for drug delivery system.

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