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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A new red-emissive two-photon fluorescence dye for designing bioprobes

등록일
2015년 2월 26일 16시 53분 26초
접수번호
1507
발표코드
ORGN.P-910 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
시호영, 김환명*
아주대학교 에너지시스템학부, Korea
Two-photon microscopy (TPM) utilizes two photons of lower energy to obtain the excited state of a fluorophore, and thus has more advantageous features over OPM including less phototoxicity, better three dimensional spatial localization, deeper penetration depth and lower self-absorption. However, the progress in this field remains challenging, in large part due to the lack of useful TP scaffolds for designing various TP probes. Red emissive fluorescent probes are attractive for imaging in live cells and tissues, because they have better spectral separation from cellular absorption and auto fluorescence than probes that emit in the blue to yellow fluorescence range, thereby enhancing the contrast between the readout and background emission.1 We have developed a red emissive fluorescence dye (BTDAN-ex) derived from 6-(benzo[d]thiazol-20-yl)-2-(N,N-dimethylamino)naphthalene(BTDAN). BTDAN-ex shows 40~80nm red-shifted spectra than BTDAN. The BTDAN-ex is expected to be applying in various ways, for example as a tracker for targeting specific organelles such as lysosome, mitochondria or as a fluorophore attached to receptor to detect specific metal ion.

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