abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Dynamic Nuclear Polarization: Sensitivity Enhancement for Multi-molecular Magnetic Resonance Imaging Agents

등록일
2015년 2월 12일 16시 28분 12초
접수번호
2042
발표코드
ANAL.O-42 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 11시 : 22분
발표형식
구두발표
발표분야
분석화학 - Oral Presentation of Young Analytical Chemists
저자 및
공동저자
정기진, 고혜지, 공경현, 이영복*
한양대학교 응용화학과, Korea

Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-13C pyruvic acid. The CRIMP method is a simple versatile chemical method that can be done without any physical changes to the dissolution pathway or to the polarizer. Many new techniques in the literature including cross polarization, microwave frequency modulation, generating a faster dissolution or injection setup and increasing the magnetic field from dissolution to scanner are all physical methods used to increase hyperpolarization percentages or to increase the T1 value of hyperpolarized imaging compounds. The new method can potentially be applied to study several in vivo metabolic pathways and multiple biochemical reactions concurrently in real-time.


상단으로