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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Oxidation of zinc fingers and their binding events to nucleic acids

등록일
2015년 8월 8일 04시 33분 11초
접수번호
0017
발표코드
INOR2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 25분
발표형식
심포지엄
발표분야
무기화학 - Recent Trends in Bioinorganic Chemistry
저자 및
공동저자
이승재
전북대학교 화학과 , Korea
Zinc finger proteins use zinc as a structural co-factor to function, typically by binding to nucleic acids with sequence specificity. Although zinc is typically thought to be the physiologically relevant metal ion for zinc finger protein function there is evidence that other metal ions, including iron, may replace zinc under certain conditions. Studies on iron binding to two zinc finger proteins, NZF-1 and ST-18 will be presented. Neural Zinc Finger-1 has two zinc binding domains each of which is composed of three cysteine and one histidine residues (Cys2His1Cys1) that bind zinc. ST-18 is a non-classical zinc finger protein that contains six zinc binding domains of the form Cys2His1Cys1. Peptides corresponding to the zinc binding domains of NZF-1 and ST-18 were prepared and their zinc, iron and DNA binding properties were determined. These results will be further applied for the development of new inhibitors of neuronal diseases.

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