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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 DEVELOPING VERSATILE NANOCARRIER USING AFFIBODY/POLYMERIC NANOGEL HYBRID COMPLEXES [세진시아이 포스터상]

등록일
2015년 8월 27일 11시 28분 11초
접수번호
0583
발표코드
BIO.P-176 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
김한솔, 강세병1,*
울산과학기술대학교(UNIST) 생명과학, Korea
1울산과학기술대학교(UNIST) 나노생명화학공학부, Korea
Binding specificity and high affinity to any given target molecules are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Recently, affibody has been widely used as ligands for targeted delivery of therapeutics and/or diagnostics. Affibody, especially, has been used to enrichment of low abundant molecules in complex samples, and specific detections of biomarkers in vitro and/or in vivo, because they have much smaller size compared with antibody, but it has enough binding affinity and specificity to their target molecules. We developed versatile affibody/nanoparticle hybrid complexes as multifunctional theranostic nanocarriers by combining affibody-GST fusion proteins with highly stable polymeric nanogels (NG) which encapsulate anticancer drug, doxorubicin through thiol-disulfide exchange. These hybrid theranostic nanocarriers (Affibody/NG complexes) show high target specificity and the enhanced efficacy. Furthermore, multifunctional hybrid theranostic complexes will be developed by mixing and matching strategy.

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