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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Phenyl Selenium-Based Small Molecular Probes for Detection of Biological Analytes: ROS and Biothiols

2015년 8월 27일 15시 37분 45초
KCS.O-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 09시 : 20분
Oral Presentation for Young International Chemists
저자 및
SANDIP MULAY, D.G.Churchill*
한국과학기술원(KAIST) 화학과, Korea
Organoselenium molecular probes show great promise in the detection of biological analytes such as ROS and biothiols in living biological systems. Among ROS, HOCl is a potential antimicrobial agent that plays a significant role in the human immune-defense system.1 However, abnormal HOCl levels in living organisms can lead to diseases such as atherosclerosis, rheumatoid arthritis, lung injury, cancer, neurodegenerative disorders, and kidney and cardiovascular disease. Biothiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play crucial roles in biological systems. GSH plays a central role in protecting the cell from oxidative damage and in maintaining biological homeostasis which plays a significant role in cell growth and function.2 These biological species are thought to play important roles for normal physiological processes; an overproduction or deficiency of them can be indicative of cancer, neurodegenerative disease disorders such as Alzheimer’s and Parkinson’s disease, cystic fibrosis, AIDS, osteoporosis, cardiovascular disease and sickle cell anemia.3 Hence, selective determination of these species is required for a better understanding of their role in biological systems and in early diagnosis of disease. The details of synthesis, screening, biological studies and general application of phenyl selenium-based small molecular probes will be discussed in this presentation.4 References: 1. Hampton, M. B.; Kettle, A. J.; Winterbourn, C. C. Blood 1998, 92, 3007. 2. Hyman, L. M.; Franz, K. J, Coord. Chem. Rev. 2012, 256, 2333. 3. Townsend, D. M.; Tew, K. D.; Tapiero, H. Biomed. Pharmacother. 2003, 57, 145. 4. Kim, Y.;‡ Mulay, S. V.;‡ Choi, M.; Yu, S. B.; Jon, S.; Churchill, D. G. Chem. Sci. 2015, (DOI: 10.1039/C5SC02090E).