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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Preparation of 4-arm PCL-b-PLA-b-PMVK Triblock Copolymer as Biodegradable Microparticles by RAFT Polymerization

등록일
2015년 8월 27일 15시 58분 00초
접수번호
0944
발표코드
POLY.P-59 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
고분자화학
저자 및
공동저자
이소림, 정일두*
부산대학교 고분자공학과, Korea
Biodegradable triblock copolymers based on 4-arm polycaprolactone (PCL) were synthesized by ring opening polymerization of PLA followed by RAFT polymerization of poly(methyl vinyl ketone)(PMVK). Microspheres based on 4-arm triblock copolymers were prepared by emulsion-evaporation method, and then photodegraded with UV irradiation to obtain porous microparticles. In order to polymerize by RAFT method, PCL-PLA based macro-CTA (chain transfer agent) was first synthesized by reacting carboxylic acid-terminated CTA with PCL-PLA, and used to synthesize triblock copolymer with methyl vinyl ketone (MVK). The morphology of the particles before and after UV irradiation were confirmed by SEM and TEM images and the release studies of paclitaxel, anti-cancer agent for female cancers from the particles were evaluated by HPLC. PCL-PLA based biodegradable microparticles will be anticipated to enhance drug release and could find potential application for biomaterials.

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