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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rhodium-Catalyzed Reaction of Azobenzenes with Diazotized Meldrum’s Acid

등록일
2015년 8월 27일 16시 05분 40초
접수번호
0964
발표코드
ORGN.P-381 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
손정유, 이은숙, 이필호*
강원대학교 화학과, Korea
Nitrogen heterocycles are a very significant class of compounds because of their pharmaceutical applications and biological activities. Especially, cinnolin-3(2H)-ones are constituents of key privileged azaheterocyclic scaffolds. Thus, the establishment of robust synthetic approaches for affording substituted cinnolin-3(2H)-one from easily available compounds has been continuously demanded. Recently, we reported a myriad of C-H activation using phosphoryl group as a directing group and an efficient synthetic method of 2-aryl-2H-benzotriazoles from azobenzenes and N-sulfonyl azides via sequential Rh-catalyzed amidation and oxidation in one pot. In our current program involved with the synthesis of nitrogen heterocycles using azobenzenes, we envisioned that reaction of azobenzenes with diazotized Meldrum’s acid would provide a cinnolin-3(2H)-one skeleton. Herein, we describe a synthetic method of a wide range of cinnolin-3(2H)-one derivatives is developed from the reaction of symmetrical as well as unsymmetrical azobenzenes with diazotized Meldrum’s acid via Rh-catalyzed C-H alkylation followed by cyclization.

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