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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rhodium-Catalyzed Cyclization of N-Sulfonyl-1,2,3-triazoles with Bromocyanides : Synthesis of 2-Bromoimidazoles

등록일
2015년 8월 27일 16시 05분 41초
접수번호
0966
발표코드
ORGN.P-382 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이은숙, 최원석, 이필호*
강원대학교 화학과, Korea
Imidazoles are a significant scaffold of azaheterocyclic compounds, which are extensively used in biologically active compounds, in ionic liquids, and as precursors of stable carbene ligands. Consequently, development of synthetic routes of highly functionalized imidazoles from easily accessible starting materials has been a continuing challenge in modern organic synthesis. We developed a synthetic method for 2-bromoimidazoles from Rh-catalyzed cyclization of N-sulfonyl-1,2,3-triazoles with bromocyanides. Cu-catalyzed [3+2] cycloaddition followed by Rh-catalyzed cyclization starting from alkynes, N-sulfonylazides, and bromocyanides is also demonstrated for de novo synthesis of 2-bromoimidazoles in one pot. Moreover, this work was successfully employed to introduce diverse functional groups to the 2-position of imidazoles via cross-coupling reaction.

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