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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Real-time detection of nitric oxide generated from plasma using a perfluorinated xerogel-derived amperometric microsensor

2015년 8월 27일 16시 06분 48초
ELEC.P-536 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (금요일) 13:00~14:30
저자 및
신소민, 이진선, 최경훈1, 양현희, 박민지, 박봉주2, 신재호*
광운대학교 화학과, Korea
1광운대학교 플라즈마바이오과학센터, Korea
2광운대학교 전자바이오물리학과, Korea
A contact dielectric barrier discharges (DBD) plasma has recently been employed in emerging novel biomedical applications, including bacterial decontamination and chronic wound treatment. Such antimicrobial and healing efficacies may be related to the formation of reactive oxygen and nitrogen species (ROS and RNS; e.g., OH·, O2·?, NO, ONOO·?, and H2O2) by plasma exposure. Among several reactive species, nitric oxide (NO) has been extensively studied due to its phagocytic and antithrombotic activities, and angiogenic property. In order to treat the plasma to the skin for the purpose of chronic wound treatment, Rather than direct treatment of plasma, it is necessary indirect treatment. For these reasons, after it has been placed on the wound by introducing the hydrogel, it was treated with plasma. However, studies on NO generation via plasma treatment in biological milieu have been hindered due to no appropriate method for the measurement of NO. Herein we employ an electrochemical NO sensor to measure NO concentration generated by a contact DBD plasma in hydrogel. The working Pt electrode is modified with perfluorinated xerogel membrane to improve sensor’s selectivities over readily oxidizable interfering species and other ROS and RNS produced during plasma radiation. Furthermore, direct, real-time detection of NO generated in hydrogel by plasma treatment will be performed by using an NO-sensing microelectrode (a conical tip size = <100 mm). Indeed, NO has a critical role in human immunology.