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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Distinct modulation of hepatic metabolites by non-alcoholic fatty liver disease

등록일
2015년 8월 27일 16시 07분 19초
접수번호
0969
발표코드
BIO.P-205 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
민순기, 류도현, 황금숙1,*
성균관대학교 화학과, Korea
1한국기초과학지원연구원 통합대사체연구그룹, Korea
Non-alcoholic fatty liver disease are rapidly increased worldwide and recognized as a risk factor for diabetes, cardiovascular disease, obesity and renal disease. To investigate metabolic changes by NAFLD in obese mice, we performed metabolic profiling and biological analysis of liver tissues. In this study, we used diabetes models; db/db mice (C57BL/6J-db/db). Twenty-week-old male db/db and wild type (WT) mice were fed normal standard diet chow (ND). Then, we applied metabolic profiling based on ultra-performance liquid chromatography/quadrupole time-of flight mass spectrometry (UPLC/Q-TOF MS) and nuclear magnetic resonance (NMR) to find metabolic differences between two groups. Both of multivariate statistical analysis derived from MS and NMR data of liver tissue extracts showed clear metabolic differences between WT and db/db mice. This study identified features of hepatic metabolism of mice which induced NAFLD, and demonstrated that a combined approach based on MS and NMR analysis is a useful method to investigate the metabolic changes induced by NAFLD and understand their metabolism.

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