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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Molecular Interactions of Graphene Oxide with Aromatic Amino Acids

등록일
2015년 8월 27일 16시 13분 15초
접수번호
0981
발표코드
PHYS.P-262 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
강태종*, 우진국
대구대학교 화학과, Korea
Graphene oxide with functional groups of carboxylic acid, hydroxyl, and epoxide drew a great deal of attention as a promising nanomaterial for use in biosensors because of its ability of DNA adsorption as well as fluorescence quenching. Understanding the interaction between graphene oxide and the biomolecules is important for graphene oxide based bio-sensing applications. In this work, non-covalent interactions between graphene oxide and aromatic amino acids, tryptophan and tyrosine was studied by steady-state and time-resolved fluorescence measurements. Based on strong fluorescence quenching of Tyr and Trp by GO, the graphene was found to interact strongly with the amino acids. The fluorescence quenching mechanisms were investigated and the binding constants are estimated. The apparent Stern-Volmer quenching constants of GO-amino acid interactions were estimated to be similar for both Tyr and Trp (1.88x104 mL/g for Tyr and 1.93x104 mL/g for Trp). From the ab initio MD simulations, different binding sites are suggested for tryptophan and tyrosine on graphene oxide and binding energies were estimated. It is suggested that fluorescence quenching of Tyr and Trp occurs through various non-covalent intermolecular interactions such as hydrogen bonding interactions and π-π interactions.

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