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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Lipid profiling of human atherosclerotic aorta based on liquid chromatography/mass spectrometry

등록일
2015년 8월 27일 16시 14분 28초
접수번호
0983
발표코드
BIO.P-206 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
정선희, 정영애1, 남미소, 류도현, 황금숙1,*
성균관대학교 화학과, Korea
1한국기초과학지원연구원 통합대사체연구그룹, Korea
Atherosclerosis is the main cause of mortality in industrialized countries. However, only a limited number of studies on atherosclerosis was proceeded in lipid profiling of human tissue. In the present study, we performed the lipid profile of atherosclerotic aorta extracts and normal aorta extracts of human using ultra-performance liquid chromatography/quadrupole time-of flight mass spectrometry (UPLC/Q-TOF MS). Partial least squares-discriminant analysis (PLS-DA) plots showed a clear differentiation between atherosclerotic aorta extracts and normal aorta extracts. Significantly altered lipid metabolites were ceramide (Cer), lysophosphatidylcholine (lysoPC), phosphatidylcholine (PC), phosphatidylethanolamines (PE), phosphatidylinositol (PI), sphingomyelin (SM), diacylglycerol (DG) and triacylglycerol (TG) species and those lipid metabolites were elevated in atherosclerotic aorta. Particularly, lysoPC and Cer species were highly increased in atherosclerotic aorta. These results showed that lysoPC and Cer were associated with development of atherosclerosis. This study demonstrated that UPLC/Q-TOF MS based lipid profiling can be useful tool to understand lipid distribution of human atherosclerotic aorta and may provide the insight for pharmacotherapeutic intervention.

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