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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Plasmonic gold nanoparticles for sensitive photoacoustic imaging and visible-light induced graphene oxide reduction

2015년 8월 27일 16시 19분 33초
MAT.P-449 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (금요일) 13:00~14:30
저자 및
KumarDinesh, 이아름, 강은미1, 배유민2, 임동권3,*
고려대학교 NBIT, Korea
1숭실대학교 화학과, Korea
2고려대학교 ku-kist 융합대학원, Korea
3고려대학교 KU-KIST 융합대학원, Korea
Strong light absorption and scattering properties in the visible and near-infrared (NIR) region have been extensively explored plasmonic gold nanoparticles for their use in numerous photochemical and biological applications. Here, we have highlighted the performance of gold nanostructures for visible light induced graphene oxide reduction at room temperature and hybrid graphene oxide based plasmonic nanoparticles (gold nanoparticles (AuNPs) and gold nanorods (AuNRs)) for sensitive photoacoustic imaging. The use of visible light with plasmonic nanoparticles (AuNPs) has been proved to be a simple, chemical free, and energy efficient method to produce r-GO.1,2 The reduced graphene oxide prepared using visible light showed excellent fluorescence quenching properties and target detection capabilities. On the other hand, reduced graphene oxide coated gold nanorods (r-GO-AuNRs) due to the excellent NIR light absorption properties and highly efficient heat transfer process through the reduced graphene oxide layer, exhibits excellent photothermal stability and significantly higher photoacoustic amplitudes (in the 4-11 MHz operating frequency of an ultrasound transducer) than bare-AuNRs, graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNRs, as demonstrated in both in vitro and in vivo systems. A four times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs as suggested by finite-element-method simulation studies. The excellent optical stability of AuNRs along with its ability to amplify the photoacoustic amplitude (PA) signal intensity and a relatively straightforward surface chemistry of r-GO (via covalent or noncovalent modifications of the ligand on the r-GO layer, which is essential for drug delivery systems) anticipated r-GO-AuNRs to be an promising theranostic agent.3 Therefore, the r-GOAuNRs can be useful for sensitive disease diagnosis, as vehicles for therapeutic drug delivery, and for NIR sensitive photothermal therapy.

1. Dinesh Kumar, Sandeep Kaur, Dong-Kwon Lim, Chemical Communications, 2014, 50, 13481-13484.
2. D. Kumar, Ah-Reum Lee, Sandeep Kaur, Dong-Kwon Lim, Journal of Visualized Experiments, 2015 (DOI: doi:10.3791/53108).
3. Hyungwon Moon, Dinesh Kumar, Hyemin Kim, Changbeom Sim, Jin-ho Chang, Jung-Mu Kim, Hyuncheol Kim, and Dong-Kwon Lim, ACS Nano, 2015, 9, 2711-2719.