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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and characterization of covalent bonded chlorin derivatives on graphene oxide nanosheets for photodynamic theraphy

2015년 8월 27일 16시 49분 13초
MEDI.P-505 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (목요일) 11:00~12:30
저자 및
강은선, 심영기1,*, 윤일2
인제대학교 나노융합공학과, Korea
1인제대학교 나노융합공학부, Korea
2인제대학교 PDT 연구소, Korea
Photodynamic therapy (PDT) is a relatively new cancer modality that uses light, photosensitizer (PS), and oxygen for the treatment of various forms of cancer using photodynamic action. The PDT treatment derives great promise from the dual selectivity that is produced by both a preferential uptake of the drug by the diseased tissue and the restriction of carefully regulated light absorption onto the specific tumor sites. Graphene, a very recent rising star material, having an atomically thin, 2D honeycomb lattice that consists of sp2-hybridized carbons, exhibits remarkable electronic, thermal, optical, and mechanical properties. Particularly, graphene oxide (GO), graphene’s hydrophilic derivative, has been found important potential applications in drug delivery due to their large specific surface area and abundant functional groups (epoxide, hydroxyl, and carboxyl groups). GO nanosheets were prepared by a modified Hummers' method. Chlorin derivatives having versatile functional groups (carboxyl, hydroxyl, aldehyde, amine) were synthesized from chlorophyll-a paste followed by extraction, oxidation, and imide formation. The chlorin derivatives were covalent bonded on the GO nanosheets through various synthetic methods contain coupling reactions (-COO- bond), click reaction (triazole ring formation), and N-alkylation (N-C bond) reaction. Finally, the covalent bonded chlorin derivatives on the GO nanosheets were characterized using a combination analysis by FT-IR, NMR, UV-vis, Raman spectroscopies, XPS and TGA analyses, and TEM images.