abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Copper-Catalyzed Diastereoselective Addition of 1,1-Alkyldiboronates to N-tert-Butanesulfinylaldimines: Synthesis of β-Aminoboronates

등록일
2015년 8월 27일 16시 52분 20초
접수번호
1062
발표코드
ORGN.P-395 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박진영, 김정훈, 조승환*
포항공과대학교(POSTECH) 화학과, Korea
The nucleophilic addition of organometallic reagents to imines bearing a chiral auxiliary offers a powerful synthetic strategies with a potential to access to chiral α-branched amines, which are prevalent in natural products, pharmaceuticals, and asymmetric catalysts. Among many strategies available, the diastereoselective addition of organometallic reagents to N-tert-butanesulfinylimines has been considered as one of the most reliable and efficient methods for the synthesis of chiral α-branched amines.] As a result, the development of efficient and selective 1,2-addition to N-tert-butanesulfinylimines procedures has been the focus of intensive research. Despite these significant progress, the development of diastereoselective 1,2-addition using alkylboron reagents remains largely undeveloped. In this poster, we will describe the first chemo- and diastereoselective alkylation reaction of 1,1-alkyldiboronates to N-tert-butanesulfinylaldimines catalyzed by copper salt and achiral bidentate phosphine ligand. The reaction provides β-aminoalkylboronates, which can be further elaborated through oxidation or functionalization to generate synthetically valuable intermediates in organic synthesis.

상단으로