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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Pikromycin and the Beyond: A Case of Natural Product Synthesis

2015년 9월 2일 17시 50분 21초
ORGN1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 15시 : 15분
유기화학 - Division of Organic Chemistry Symposium I
저자 및
충북대학교 화학과, Korea

Macrolide antibiotics are a group of compounds that contains a macrolactone ring to which one or more sugars are attached. Although erythromycin has played a leading part in macrolide research, pikromycin is actually the first isolated macrolide antibiotics. Pikromycin is similar to erythromycin in structure because, it possesses a 14-membered macrolactone, pikronolide. However, it has only a single sugar, that is, desosamine attached to one of the hydroxy groups of the macrolactone ring. Pikromycin has recently regained attention as a promising target for biosynthetic studies due to fact that during its biosynthetic pathway, a series of macrolides are produced. Because as many as eight possible macrolides are produced by the polyketide synthase in Streptomyces venezuelae, it has emerged as an ideal target system for the biosynthetic study in relation to combinatorial biosynthesis. Inspired by the genetic study on the pikromycin biosynthesis, we have been involved in the total synthesis of macrolides appeared in the pikromycin biosynthesis with an aim of facilitating the biosynthetic research. As a result, total synthesis of pikromycin and related macrolides has been successfully achieved. Because the main reason that pikromycin and the related macrolides are relatively unknown might be ascribed to their low antibacterial activity, we have also made an effort to improve their biological activity.