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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Crystal structure of Triosephosphate Isomerase from Clonorchis sinensis

등록일
2015년 9월 3일 13시 48분 39초
접수번호
1222
발표코드
BIO.P-215 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
손종현, 김설희, 황광연1,*
고려대학교 바이오시스템공학과, Korea
1고려대학교 생명공학부, Korea
Clonorchis sinensis is a parasitic flatworm that can cause clonorchiasis in East Asia [1]. In 2009, International Agency of Cancer Research reclassified C. sinensis as a group 1 biological carcinogen because this trematode is known to cause cholangiocarcinoma [2]. Triosephosphate isomerase (TIM), a key enzyme in glycolysis, catalyses the reversible isomerization of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde 3-phosphate (GAP). Since its role in energy metabolism is considerable, it has been regarded as a major drug target [3]. Recent study has been reported that many parasitic flatworms have a similar tripeptide insert (SXD/E) in TIM [4]. Here, we determined the crystal structure of TIM from Clonorchis sinensis (CsTIM) at 1.75 Å resolution. Interestingly, inserted tripeptide of CsTIM was exposed to the surface and formed a short rigid-helix in contrast to a loop of the corresponding portion in chicken TIM. It might be plausible to develop a vaccine against C. sinenesis based on the insert of tripeptide that does not exist in TIM of host such as human.

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