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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of a chemical-based potent anti-bacterial agent and a novel small molecule-based theragnostic agent for disease

2015년 9월 3일 14시 37분 40초
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금 11시 : 00분
저자 및
한양대학교 화학과, Korea
In anti-bacterial agent research, we have focused on enzymatic mechanism of acetohydroxyacid synthase (AHAS) and development of their potent inhibitors. The AHAS as a novel target is known to catalyze at the first stage for biosynthesis of an essential branched chain amino acid (BCAA) synthesized by plants and bacteria not by animals. In our research, we have identified and characterized functional and structural features of AHAS from various bacteria (M. tuberculosis, H. influenzae, B. anthracis, E. coli, S. sonnei, P. aeruginasae, and E. faecalis) and screened a chemical inhibitors via high-throughput screening (HTS) technique. The most of found inhibitors are exhibited a strong inhibitory effect in bacterial strains, thus the AHAS could be a potent anti-bacterial target. In addition, we have studied a novel theragnostic agent based on small molecular probe such as peptide and aptamer produced by phage display and SELEX technique. In order to evaluate the probes as a therapeutic agent, we have developed peptide/aptamer against a various target molecules as biomarkers in a particular disease; Tuberculosis (AHAS), Anthrax (anthrax toxins), Citrus canker (FtsZ), and Phytophthora blight (tubulins). The most of probes did not only exhibit a strong binding ability, but also the potent inhibition effect in their target. At a time, we have also focused on development of diagnostic probes against various diseases; Anthrax, Alzheimer’s disease, Cancer, Foodborne pathogens, Antibiotics, and Endocrine disrupters. In order to enhance a probe-sensitivity and selectivity, we have further developed a polyvalent directed probe polymer (PDPP) and applied a novel biological sensor systems for early diagnosis of diseases with a diverse convergence techniques. Consequently, we suggest that the peptide or aptamer would be prospected a potent candidate and could be used in disease therapy and diagnosis.