언론에 비친 KCS
후원사 혜택 안내
지면 광고 안내
소개 및 활동/사업
현재 가능한 작업은 아래와 같습니다.
09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Development of a chemical-based potent anti-bacterial agent and a novel small molecule-based theragnostic agent for disease
2015년 9월 3일 14시 37분 40초
이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 11시 : 00분
한양대학교 화학과, Korea
In anti-bacterial agent research, we have focused on enzymatic mechanism of acetohydroxyacid synthase (AHAS) and development of their potent inhibitors. The AHAS as a novel target is known to catalyze at the first stage for biosynthesis of an essential branched chain amino acid (BCAA) synthesized by plants and bacteria not by animals. In our research, we have identified and characterized functional and structural features of AHAS from various bacteria (
) and screened a chemical inhibitors via high-throughput screening (HTS) technique. The most of found inhibitors are exhibited a strong inhibitory effect in bacterial strains, thus the AHAS could be a potent anti-bacterial target. In addition, we have studied a novel theragnostic agent based on small molecular probe such as peptide and aptamer produced by phage display and SELEX technique. In order to evaluate the probes as a therapeutic agent, we have developed peptide/aptamer against a various target molecules as biomarkers in a particular disease; Tuberculosis (AHAS), Anthrax (anthrax toxins), Citrus canker (FtsZ), and Phytophthora blight (tubulins). The most of probes did not only exhibit a strong binding ability, but also the potent inhibition effect in their target. At a time, we have also focused on development of diagnostic probes against various diseases; Anthrax, Alzheimer’s disease, Cancer, Foodborne pathogens, Antibiotics, and Endocrine disrupters. In order to enhance a probe-sensitivity and selectivity, we have further developed a polyvalent directed probe polymer (PDPP) and applied a novel biological sensor systems for early diagnosis of diseases with a diverse convergence techniques. Consequently, we suggest that the peptide or aptamer would be prospected a potent candidate and could be used in disease therapy and diagnosis.
등록된 그림이 있는경우 그림을 클릭하시면 원본 그림파일을 볼 수 있습니다.
최종본을 확인하지 않아 발생된 문제에 대해서는 책임지지 않습니다.
미리보기의 그림위치는 임시 위치입니다. 모든 그림파일은 Abstract 하단에 위치하게 됩니다.