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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Design, synthesis and biological evaluation of Diarylurea derivatives as potential anticancer agents

등록일
2015년 9월 3일 14시 53분 40초
접수번호
1249
발표코드
MEDI.P-517 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Mahmoud Mahmoud Mohamed Gamal EIDin, 유경호1, 오창현2,*
과학기술연합대학원대학교(UST) 의약화학, Korea
1한국과학기술연구원(KIST) 화학키노믹스연구센터, Korea
2한국과학기술연구원(KIST) 바이오소재연구센터, Korea

A novel series of 2,5-disubstituted-1,3,4-oxadiazole containing urea linker were designed and synthesized. Their in vitro antiproliferative activities were examined over a panel of 60 cancer cell lines of 9 different cancer types at the National Cancer Institute (NCI, Bethesda, Maryland, USA). The compounds tested showed promising anticancer activity compared to sorafenib. At a single dose concentration of 10 ?M, many target compounds exhibited cytotoxic effect with more than 100% inhibition over different cell lines of different cancer types. For example, compound 1e showed 184% inhibition over Colo-205, and 137.9% inhibition against SK-Mel 2. Compound 1j inhibited the growth of Colo 205 colon cancer cell line, SK-Mel 2 melanoma cell line and MDA-MB-231/ATCC breast cancer cell line by 140%, 132.87% and 122.63%, respectively. The inhibition % of compound 1m were 154%, 125.42%, and 126.57% against NCI-H522, NCI-H460 non small cell lung cancer cell lines, and U 251 CNS cancer cell line. We are currently waiting for 5-dose results and the remaining one dose results.


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