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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Shaping fluorescence by protein shapes in GFP

등록일
2015년 9월 3일 15시 04분 39초
접수번호
1252
발표코드
KCS3-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
수 16시 : 10분
발표형식
심포지엄
발표분야
Quantum Chemistry: An Essential Tool for Modern Chemistry
저자 및
공동저자
이영민
포항공과대학교(POSTECH) 화학과, Korea
The green fluorescent protein (GFP) with great utilities in many different fields is also an interesting but challenging target from a physical chemist’s point of view. It can also baffle theoreticians as its understanding often requires adopting expensive high level quantum chemical methods. Here, we will discuss the fluorescence modulation in GFP system based on dynamics simulations with a quantum chemically constructed potential energy surface. By computationally modulating the electrostatic interactions between the chromophore phenoxy oxygen and its nearby residues, we demonstrate that the emission can shift to the blue or to the red side in a very predictable manner. We will also see that the yellow fluorescent protein (YFP), with a tyrosine residue replacing threonine in the direct vicinity of the chromophore, involves a chromophore conformational change and a new ?-stacking interaction, which in turn generate red shifts to send the fluorescence into the yellow region. With the series of demonstrations, we show that the analytical approaches such as ours can provide solid rationales on different responses of the fluorescent protein.

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