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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Co-solvent’s Effect on Solute-Solvent Hydrogen-Bond Dynamics: Ultrafast 2D IR Investigations [우수포스터상]

2015년 9월 3일 15시 50분 18초
PHYS.P-284 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (금요일) 13:00~14:30
저자 및
백호용, 이인성, 김영삼*
울산과학기술대학교(UNIST) 자연과학부 화학과, Korea
Co-solvents strongly influence the solute-solvent interactions of biomolecules in aqueous environment and have profound effects on the stability and activity of several proteins and enzymes. Experimental studies have previously reported on the hydrogen-bond dynamics of water molecules in the presence of co-solvent, but understanding the effect from a solute’s perspective could provide a greater insight towards protein stability. Our study uses 2D IR spectroscopy to investigate how DMSO as a co-solvent affects the dynamics of hydrogen-bonding interactions between the C=O group of ethyl acetate and water by quantitatively estimating the hydrogen-bond exchange rate with and without DMSO in aqueous solution. 2D IR results show spectral signatures of a chemical exchange process; the presence of the co-solvent is found to lower the hydrogen-bond exchange rate by a factor of 5. The measured exchange rates are 6.68×1011 s-1 and 1.48×1011 s-1 in neat water and 1:1 DMSO/water, respectively. The widely different hydrogen-bond lifetimes and exchange rates with and without DMSO indicate a significant change in the ultrafast hydrogen-bond dynamics in the presence of a co-solvent, which in turn might play an important role in the stability and activity of biomolecules.