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제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Preparation and characterization of lipid vesicles using dynamic light scattering and asymmetrical flow field-flow fractionation

2015년 9월 3일 16시 11분 44초
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10월 16일 (금요일) 13:00~14:30
저자 및
한수정, 최재영, Lars Nilsson1, Haiyang Dou2, 이승호*
한남대학교 화학과, Korea
1Department of Food Technology, Lund University, Sweden
2Hebei University, China
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승인 2건
Vesicles are spherical shells composed of lipid bilayers that encapsulate an aqueous space. They have been used frequently as model membranes, and as nanoscale containers for drugs and other substance in the pharmaceutical and cosmetic industries. When vesicles are used for drug delivery, the stability (and the life-time) of the vesicles is directly related with their medicinal effect. Generally the stability of vesicles is related with the size and size distribution of the vesicle. Thus size characterization of vesicles is necessary for understanding of the vesicle stability. The dynamic light scattering (DLS), optical microscopy (OM), electron microscopy (EM), nuclear magnetic resonance (NMR) and nanoparticle tracking analysis (NTA) have been used for size analysis of particulate materials. Among them, DLS is simple to use, and has been widely used for measuring the particle size and its distribution. Sometimes, however, application of DLS is limited, especially when dealing with samples of complex mixtures or those of broad size distributions. Field-flow fractionation (FFF) is useful for separation and size characterization of particles having broad size distributions from a few nm up to about 100 μm. Asymmetrical flow field-flow fractionation (AsFlFFF), a member of FFF, is useful particularly for characterization of aqueous colloidal particles. In this study, nano-sized vesicles were prepared by extrusion, and then were analyzed by AsFlFFF for determination of the particle size distribution and for the stability test. Results from DLS and AsFlFFF were then compared.