abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Preparation and characterization of lipid vesicles using dynamic light scattering and asymmetrical flow field-flow fractionation

등록일
2015년 9월 3일 16시 11분 44초
접수번호
1279
발표코드
ANAL.P-343 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
한수정, 최재영, Lars Nilsson1, Haiyang Dou2, 이승호*
한남대학교 화학과, Korea
1Department of Food Technology, Lund University, Sweden
2Hebei University, China
※ 국외소속으로 등록된 저자의 승인여부는 최소 3일이내 발표자 email로 알려드립니다.
승인 2건
Vesicles are spherical shells composed of lipid bilayers that encapsulate an aqueous space. They have been used frequently as model membranes, and as nanoscale containers for drugs and other substance in the pharmaceutical and cosmetic industries. When vesicles are used for drug delivery, the stability (and the life-time) of the vesicles is directly related with their medicinal effect. Generally the stability of vesicles is related with the size and size distribution of the vesicle. Thus size characterization of vesicles is necessary for understanding of the vesicle stability. The dynamic light scattering (DLS), optical microscopy (OM), electron microscopy (EM), nuclear magnetic resonance (NMR) and nanoparticle tracking analysis (NTA) have been used for size analysis of particulate materials. Among them, DLS is simple to use, and has been widely used for measuring the particle size and its distribution. Sometimes, however, application of DLS is limited, especially when dealing with samples of complex mixtures or those of broad size distributions. Field-flow fractionation (FFF) is useful for separation and size characterization of particles having broad size distributions from a few nm up to about 100 μm. Asymmetrical flow field-flow fractionation (AsFlFFF), a member of FFF, is useful particularly for characterization of aqueous colloidal particles. In this study, nano-sized vesicles were prepared by extrusion, and then were analyzed by AsFlFFF for determination of the particle size distribution and for the stability test. Results from DLS and AsFlFFF were then compared.

상단으로