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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of 1-Unsubstituted-NH-1,2,3-Triaozle by Copper Aerobic Oxidation from α-(1,2,3-Triazol-1-yl)acetophenones

등록일
2015년 9월 3일 16시 51분 00초
접수번호
1299
발표코드
ORGN.O-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 00분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation of Graduate Scholars in Organic Division
저자 및
공동저자
차효진, 이경규, 지대윤*
서강대학교 화학과, Korea

1-Unsubsitituted-NH-1,2,3-triaozle moiety is a crucial structure in the pharmaceuticals and agrochemicals. Increasing demands of 1-unsubsitituted-NH-NH-1,2,3-triaozle require new methods to prepare conveniently, cost-efficiently and environment-friendly even in bulk scale production. Molecular oxygen among various oxidants is considered an ideal oxidant. Therefore, copper catalyzed aerobic oxidative by C-N bond cleavage for the synthesis of 1-unsubsititued--NH-1,2,3-triazole provides many merits mentioned in the above. First, copper(I)-catalyzed [3+2] cycloaddtion reactions of 1-azido-acetophenono and various substituted acetylene groups gave α-(1,2,3-triazol-1-yl)acetophenones as starting materials conveniently. The title compounds could be prepared by oxidation of alpha-carbon of α-(1,2,3-Triazole-1-yl)acetophenones with molecular oxygen and copper(II) acetate catalytic amounts. This method could be useful for the preparation of target compounds with various functional groups and neutral condition in high yield.


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