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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of a Non-invasive Probing Method for Pharmaceutical Analysis Using Spatially Offset Raman Spectroscopy

2015년 9월 3일 16시 58분 32초
ANAL2-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 00분
분석화학 - Material Sciences in Analytical Chemistry
저자 및
국민대학교 생명나노화학과, Korea
Vibrational spectroscopies, such as Infrared spectroscopy and Raman spectroscopy, should be a better solution for obtaining all information from large batch, since they only examine small volume of the sample. Furthermore, these spectroscopic methods are available for gathering molecular information including functional groups, chirality and tautomerism. They provide much valuable information, comparing with other sample selection ? and detecting methods, such as high performance liquid chromatography. Recently, an emerging new technique, spatially offset Raman spectroscopy (SORS) is a promising tool for the pharmaceutical analysis. SORS can provide more information than conventional Raman spectroscopy because it covers much larger sample size and wide depth. Also, it is non-destructive analysis tool through containers, such as bottles, sacks, and polymers. In this work, we developed SORS setup for probing mixing process of pharmaceutical ingredients. We improved the sampling and analysis speed and presented spectra with better signal to noise ratio, since this technique increases Raman signals. Also, for pharmaceutical industry, uniformity of all tablet components is essential to keep the patients’ health. So, we demonstrated this technique as an analysis tool for proving the uniformity of the tablets.