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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Modulation of Amyloid-β Aggregation Pathways by Iridium(III) Complexes

등록일
2015년 9월 4일 16시 23분 55초
접수번호
1327
발표코드
INOR2-6 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 43분
발표형식
심포지엄
발표분야
무기화학 - Recent Trends in Bioinorganic Chemistry
저자 및
공동저자
강주혜, 이신정1, 권태혁2,*, 임미희*
울산과학기술대학교(UNIST) 자연과학부/화학과, Korea
1포항공과대학교(POSTECH) 화학과, Korea
2울산과학기술대학교(UNIST) 친환경에너지 공학부, Korea
Iridium(III) complexes are known to have properties to convert triplet dioxygen into singlet dioxygen or superoxide anion upon the treatment with light. These produced reactive oxygen species are shown to oxidize peptides and proteins and further induce their crosslinking. Utilizing such properties, we have applied Ir(III) complexes to modulate the aggregation pathways of amyloidogenic peptides. The aggregated amyloidogenic peptides are found in brains of neurodegenerative disease [e.g., amyloid-β (Aβ) aggregates in the brain of Alzheimer’s disease] and are suggested to be linked to neuropathogenesis. Thus, significant efforts on developing chemical reagents capable of controlling the aggregation of amyloidogenic peptides have been recently made. Herein, we will present the synthesis, characterization, and reactivity of Ir(III) complexes, newly designed for regulating Aβ aggregation based on their photophysical properties. Some mechanistic studies for the anti-amyloidogenic activity of our Ir(III) complexes will also be discussed.

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