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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Saponarin from barley seedling attenuates adipogenesis and cholesterol metabolism in 3T3-L1 cells by regulating AMPK and PPARγ activity

등록일
2015년 9월 5일 15시 29분 08초
접수번호
1333
발표코드
MEDI.P-520 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
서우덕
농촌진흥청 국립식량과학원, Korea

Mechanism of saponarin (SA), which isolated barley seedling (BS), on adipogenesis metabolism was investigated. SA was highly purified from BS by column chromatography and determined its molecular structure by ultra performance liquid chromatography (UPLC)-QTOF-Ms/Ms and nuclear magnetic resonance (NMR) analyses. SA reduced the lipid accumulation as well as attenuated intercellular triglyceride (TG) content in mouse adipocytic 3T3-L1 cells. SA reduced the expression of the preadipocytes differentitation regulator genes such as peroxisome proliferator-activated receptor gamma (PPARγ), sterol regulatory element-binding protein-1c (SREBP-1c) activities and induced AMP-activated protein kinase (AMPK) phosphorylation without cytotoxicity. Moreover, SA was inhibited adipocytes genes expression for activator protein 2 (AP-2) and adipose triglyceride lipase (ATGL). These results indicate that SA inhibited in lipid accumulation and gene expression of adipogenic factors and decreased the TG and cholesterol level in adipocytes. The intake of BS might provide the metabolic benefits of lipid and cholesterol control. Further human studies may confirm this effect.


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