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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Polysaccharide-Based Nanoparticles Responding to Tumor Microenvironments

등록일
2015년 9월 6일 14시 49분 52초
접수번호
1335
발표코드
POLY1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 20분
발표형식
심포지엄
발표분야
고분자화학 - Polymers for Drug Delivery System
저자 및
공동저자
박재형
성균관대학교 화학공학부, Korea
Self-assembled polymeric nanoparticles have received attention as anticancer drug carriers because they can circulate in blood for long periods of time, followed by selective accumulation into tumor tissue via the enhanced permeation and retention effect. However, delivery of the drug into the intracellular compartments of the cancer cell is often insufficient due to the slow release of the drug from nanoparticles. In our group, various polysaccharide-based nanoparticles, responsive to cancer-specific stimuli, have been investigated as the drug carrier for cancer therapy. When such nanoparticles are administered into tumor-bearing mice, they selectively accumulated into the tumor site. Their in vivo tumor targetability were achieved via passive or active targeting mechanism. Once they reach the tumor site, the drug was rapidly released, primarily owing to the characteristic stimuli of tumor such as the low pH, reductive envionment, and hypoxic condition. Overall, the stimuli-sensitive polysaccharide nanoparticles might have promising potential as the carrier of the anticancer drugs.

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