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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 DNA Nanoparticles for a Tumor-Specific Anticancer Drug Carrier; Application of Rolling Circle Amplification

등록일
2015년 9월 8일 11시 57분 51초
접수번호
1366
발표코드
BIO.P-221 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
안형준
한국과학기술연구원(KIST) 테라그노시스, Korea
A rolling circle amplification (RCA) technique has been widely used for biomedical applications, but it is yet challenging to rationally design RCA products for a simple target-selective delivery of drugs to cancer cells. Here, we devise a doxorubicin nanocarrier composed of RCA products, cholesterol-DNA, and folate-DNA conjugates. RCA products, designed to contain multiple tandem repeats of short hairpin DNA, employ the repeated sequences complementary to both DNA conjugates, and thus RCA products/cholesterol-DNA/folate-DNA complexes, generated via sequential base pairing processes, acquire the amphiphilic properties that facilitate self-assembly into the highly condensed nanoparticles (RCA nanoparticles) in an aqueous environment. RCA nanoparticles cannot only accommodate doxorubicins with high cargo capacity, but also release them to the environment by the aid of acidity. Particularly, the highly condensed structures enable RCA nanoparticles to be resistant to nuclease attacks in the blood. Furthermore, doxorubicin-loaded RCA nanoparticles have specificity for folate receptors and thus show the selective cytotoxicity on the cancer cells, while minimizing their side effects on the normal cells. These results show that our strategy provides an alternative tool to exploit RCA technique on drug delivery systems and also RCA nanoparticles have great potential as a doxorubicin carrier for the targeted cancer therapy.

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