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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Systemic Delivery of siRNA to Tumors Using Rolling Circle Transcription; Dual Function of Carrier and Cargo

등록일
2015년 9월 8일 12시 09분 08초
접수번호
1368
발표코드
BIO.P-223 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
안형준*, 장미희1
한국과학기술연구원(KIST) 테라그노시스, Korea
1한국과학기술연구원(KIST) 테라그노시스연구단, Korea
For the rapeutic applications of siRNA, there are technical challenges with respect to targeted and systemic delivery. We here report a new siRNA carrier, RNAtrNPs, in a way that multiple tandem copies of RNA hairpins as a result of rolling circle transcription (RCT) can be readily adapted in tumor-targeted and systemic siRNA delivery. RNAtr NPs provide a means of condensing large amounts of multimeric RNA transcripts into the compact nanoparticles, especially without th aid of polycationic agents such as polyethylenimine, and thus reduce the risk of immunogenicity and cytotoxicity by avoiding the use of synthetic polycationic reagents. The highly condensed RNAtr NPs showed resistance to nucleases and polyanions, facilitated high cargo capacity, and finally resulted in robust gene silencing in vivo. This strategy allows the design of a platform-technology for systemic delivery of siRNA to tumor sites and also provides an alternavtive optical imaging probe for tumor visualization. Therefore, RNAtr NPs suggest great potentials as the siRNA therapeutics and imaging probes for cancer treatment.

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