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학술발표회초록보기

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 PEGylated Poly(amidoamine) Dendrimers for Drug Delivery

등록일
2015년 9월 8일 13시 09분 00초
접수번호
1370
발표코드
POLY1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 40분
발표형식
심포지엄
발표분야
고분자화학 - Polymers for Drug Delivery System
저자 및
공동저자
나동희
경북대학교 약학대학/약학과, Korea
Poly(amidoamine) (PAMAM) dendrimers are well-defined, highly branched, and globular-shaped macromolecules that have been used for many diverse biomedical applications, such as drug or gene delivery and medical imaging, but they are shown to exhibit cytotoxicity and hemolytic toxicity, depending on the surface charge and generation. In order to reduce toxicity, modification of surface amino groups of PAMAM dendrimers with PEG (PEGylation) has been often performed. Fully PEGylated PAMAMs have been studied, but in some cases partly PEGylated forms are necessary because the positive surface charge of the nanocarrier is helpful for cellular uptake. Since the number and size of PEG attached affect the usefulness of PAMAM dendrimers, the PEGylation degree and physicochemical properties should be well characterized. In this presentation, novel chromatographic methods for the determination of PEGylation degrees and purity characterization of PEGylated PAMAM dendrimers. In addition, microchip electrophoretic method for investigating difference in electrophoretic mobility between partially and fully PEGylated PAMAM dendrimers. Finally, solubilization strategy for water-insoluble or poor soluble drugs using PAMAM or PEGylated PAMAM dendrimers is presented.

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