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초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Novel fluorosulfate based fluorophores (FS-Fluor) for “Click chemistry” by sulfur fluoride exchange (SuFEx)

등록일
2015년 9월 8일 13시 33분 08초
접수번호
1373
발표코드
ORGN.P-455 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박지수, 김병문*
서울대학교 화학부, Korea

Chemical biology is essential for the investigation of biological processes in the living system. Especially, site-specific biomolecule tagging with functional groups such as fluorescent probe, spin probes, and affinity tags has been greatly utilized for understanding biological system. However, some possible drawbacks including side reactions and non-site-specific tagging have been reported. Therefore bioorthogonal chemical tools have been devised to tag biological targets within complex living systems. Among those, one of the most powerful reaction is click chemistry such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), Strain-promoted alkyne-azide cycloaddition (SPAAC) and Tetrazine-trans-Cyclooctene Ligation. On the other hand, these reactions still have problems related with residue of metal, slow reaction rate and chemical instability. Recently, sharpless et al. discovered the valuable new click reaction for biological chemistry: Sulfur(VI) Fluoride Exchange (SuFEx). Herein, we report the effectiveness of the fluorosulfate based fluorophores (FS-Fluor) applying the SuFEx in chemical biology, introducing two applications of biological chemistry; biorthogonal modification of the side chain of tyrosine derivatives and specific mitochondrial staining in cancer cells using green fluorescent tracker.


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