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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and its biological activity of α- and β-glycosyl 5,6-dihydroergosterol

등록일
2015년 9월 8일 15시 31분 14초
접수번호
1395
발표코드
ORGN.P-464 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
오현정, 김학원1,*
경희대학교 화학과, Korea
1경희대학교 응용화학과, Korea

Natural spinasterol-glucose (3-O-β-D-glucopyanosylspinasterol) has been identified as a compound not only to promote procollagen production but also to exhibit strong anti-inflammatory activity. However, spinasterol-glucose is difficult to isolate from natural plants or synthesize. To overcome these difficulties, we have already synthesized the β-glucosyl-ergosterol and β-glucosyl-5,6-dihydroergosterol (DHE), structurally similar to spinasterol, by the relatively easy synthetic method. The key intermediate 5,6-dihydroergosterol can be obtained through a selective reduction of the double bond of commercially available ergosterol. Then, we synthesize target molecules through Lewis acid-catalyzed glycosylation of trichloacetimidates with a sterol. Those molecules have been tested for biological activities on iNOS inhibition and cell viability in LPS-stimulated macrophage cells. In this report, we will describe the highly efficient synthesis of several α- and β- glycosyl-5,6-dihydroergosterol and their biological activities against skin inflammatory disease like atopic dermatitis.


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