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  • 09월 08일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제116회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Sensitive Arsenic Speciation with Capillary Electrophoresis

2015년 8월 27일 10시 14분 14초
ANAL1.O-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 09시 : 28분
분석화학 - Oral Presentation of Young Analytical Chemists I
저자 및
이호균, 권준엽, 정두수*
서울대학교 화학부, Korea
Arsenic is naturally abundant in the crust of the earth and introduced into the aquatic system through dissolution and weathering of minerals. Chronic ingestion of arsenic in water may cause various diseases, including cancer and keratosis. The World Health Organization (WHO) has set a guideline for arsenic in drinking water at 10 ppb of total arsenic. However, arsenic toxicities vary significantly depending on the species; inorganic arsenics are known to be more toxic than organic ones. Hence the quantitation of specific arsenic species may be more meaningful than the total arsenic determination for the evaluation of the health risks from arsenic-contaminated drinking water. Capillary electrophoresis (CE) provides high performance separation suitable for the determination of arsenic species in real water samples but suffers from the low detection sensitivity. We used a counter-flow (CF) electrokinetic supercharging (EKS) technique to enhance the detection sensitivity. EKS is one of the most powerful sample stacking methods that combines field amplified sample injection (FASI) and transient isotachophoresis. For further improvements in sample enrichment and separation, CF-EKS uses a counter pressure to counterbalance the movement of the stacked sample zone during FASI, obtaining a pronounced increase in the amount of sample injected and the portion of the capillary available for electrophoresis. Four arsenic compounds were analyzed by CF-EKS to obtain 6,000 to 56,000-fold enrichments. The limits of detection (LODs) were in the range of 0.08-0.3 ppb As. For a tap water sample, LODs of 0.5-3.8 ppb As were obtained after 10-fold dilution with deionized water, significantly lower than the WHO guideline of 10 ppb total As.