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제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cells are heterogeneous: the extent of heterogeneity can be understood and categorized in terms of cell dynamics

2016년 2월 18일 15시 13분 50초
PHYS.O-7 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 20분
물리화학 - 일반 구두발표 (General Oral Presentation)
저자 및
권태진, 성봉준*
서강대학교 화학과, Korea
The characteristic of the dynamical system is described by either time-averaged or ensemble-averaged variables. Unfortunately, time-average and ensemble-average quantities may often fail to represent the dynamics of cells. The time-averaged variables are often complicated due to intrinsic biological processes such as cell division and subcellular motions. The ensemble-averaged variables may lead to misinterpretation of the variables especially when cell-to-cell variation is significant in the cell population. The general approach to overcome these problems is to decompose the heterogeneous population into homogeneous subpopulations. Therefore, it is critical to set a proper criterion to categorize heterogeneous cell populations. Here we suggest the criterion by investigating the dynamics of each single cell. We consider a cell model with a large cell-to-cell variation, A549-sh-control cells, and perform by single-cell tracking experiments. We show by comparing to the simple random work model with the same diffusion coefficient of our cellular system that the dynamics of our cellular system is heterogeneous with the non-Gaussian displacement distribution. Such heterogeneous dynamics of cells can be explained by the diverse distribution of each cell’s speed and dynamic persistence. We find that the cell speed and persistence are correlated and can be employed to categorize three subpopulations. In order to verify our categorization we reproduce the diffusion of A549-sh-control cells by incorporating each subpopulation in a simple numerical simulation.