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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Tumor Imaging Using Zwitterionic Fluorogen with Aggregation-Induced-Emission Characteristics

2016년 2월 18일 16시 38분 49초
BIO.P-298 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 21일 (목요일) 11:00~12:30
저자 및
최후연, 유자형1,*
울산과학기술대학교(UNIST) Chemistry, Korea
1울산과학기술대학교(UNIST) 자연과학부 화학과, Korea
Targeted delivery of diagnostic and therapeutic agents to cancer cells has significantly received attention. For tumor specificity, the several microenvironments of cancer cells have been used such as pH difference between tumor tissue and normal tissue, overexpressed proteins and more negative membrane potentials. Using these microenvironments, a zwitterion can be the one of efficient and promising agent due to non-interacting property showing long circulation, high biocompatibility and low cytotoxicity. Also, especially, zwitterion has pH dependent charge conversion which is the most effective to tumor targeting delivery. Zwitterion is neutral at pH 7.4 (normal tissue) but changed to positively charged at tumor pH ( < 6.8). Herein, the zwitterion, acylsulfonamide group, has been used with aggregation-induced emission characteristic. At normal tissue, there is no charge of the acylsulfonamide group resulting in no cellular uptake. On the other hand, the acylsulfonamide group is becoming positive charge to enhance the cellular uptake due to highly negatively charged membrane potentials at tumor pH. Furthermore, a fluorogen with aggregation-induced-emission (AIE) has emerged to develop fluorescent probes for sensing and imaging. AIE fluorogens show highly intensive emission in the aggregated state but very weak emission in dilute solution. If this zwitterionic AIE fluorogen is accumulated in cancer cells, it can be aggregated state resulting in high emission but in normal tissue or blood stream it will be very weak emission. Therefore, we designed the zwitterionic AIE fluorogen which showed enhanced tumor imaging and sensing with fast cellular uptake at tumor pH.