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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of size-convertible nanoparticles for deep tumor tissue penetration

등록일
2016년 2월 18일 16시 46분 47초
접수번호
1735
발표코드
BIO.P-299 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 21일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
최은성, 유자형1,*, 최후연2
울산과학기술대학교(UNIST) 화학과, Korea
1울산과학기술대학교(UNIST) 자연과학부 화학과, Korea
2울산과학기술대학교(UNIST) Chemistry, Korea
For several decades, various kinds of drug delivery system(DDS) were researched for efficient tumor treatment method that can overcome limitation of drug itself, such as low stability, low water-solubility, or short blood circulation. Among many drug carriers, polymeric micelle is frequently studied because of its facile synthesis and tunable size. In our study, PEG-PDS block copolymers with different hydrophilic:hydrophobic ratio were synthesized to figure out the proper size of micelle for tumor penetration. As a preliminary study, PEG with LCST property, instead of PNIPAM which is also thermosensitive, was chosen as the first monomer. Disulfide group of PDS monomer is useful to give crosslinking site on micelles which can block the leakage of drug inside. Then, polymeric micelles would form larger complex in ~200nm size, composed of many small nanoparticles above LCST. In further research, we will study the large complex fabricated with MMP-degradable peptide to maintain large structure in physiological condition and decompose it into many nanoparticles under high MMP tumor condition, resulting release of drug deep inside the tumor tissue.

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