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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of radiolabeled nanoprobe for targeted tumor

등록일
2016년 2월 24일 17시 57분 16초
접수번호
1875
발표코드
MEDI.P-472 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 22일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
조보배, 문미미, 유국현1,*
동국대학교 화학과, Korea
1한국원자력의학원 신개념치료기술개발 플랫폼구축사업단, Korea
Radiolabeled magnetic nanoparticles are ideal probes for Positron Emission Tomography (PET)/ Magnetic Resonance Imaging (MRI) which is a powerful tool to obtain necessary information in biomedicine. Generally, 11C (t1/2=20 min), 12N (t1/2=10 min), 15O (t1/2=2 min) and 18F (t1/2=110 min) were the most used radionuclides for PET analysis. However, they have some limitations including high production cost for usage of cyclotron. To solve this obstacle, usage of metal radionuclides such as 68Ga (t1/2=68 min, β+=89 % and EC=11 %) and 64Cu(t1/2=12.7h, Iβ+=17% and Iβ-=39%, IEC=43%) were one of the alternative approach. In this present work, the radiolabeled nanoprobe were synthesized using fabricated Fe3O4 nanoparticles (NPs) with radioisotope (68Ga and 64Cu) for dual modality of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI). For labeling of radioisotope, we have used ρ-SCN-NOTA as chelating agent and 64Cu can be chelated in NHFCNP. However, 68Ga can be chelated in both NHFCNP with chelating agent and HFCNP without chelating agent very easily. Also the fabricated NPs can load drug such as DOX, anticancer agent. The nanoprobe exhibits promising application of diagnosis and therapy for tumor.

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