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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthetic study on the pyrazolo[3,4-d]pyrimidine derivatives for polo-like kinase 2 inhibitor evolution

등록일
2016년 2월 24일 17시 55분 20초
접수번호
1880
발표코드
MEDI.P-474 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 22일 (금요일) 13:00~14:30
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
함미숙, 정규성, 정찬성1,*
연세대학교 화학과, Korea
1한국과학기술연구원(KIST) 화학키노믹스연구센터, Korea
Kinases are versatile targets to investigate as these causes immunological, neurological, metabolic and infectious diseases including cancer. Protein kinases have central roles in cell proliferation, differentiation and apoptosis in physiological environment. There happened some diseases such as cancer from their abnormal activities. Several families of protein kinases are the key regulators of cell cycle progression. Especially, the Polo-like kinases are key regulator in many processes involved in cell cycle, including entry into mitosis, DNA replication and the stress response to DNA damage. In this poster, we discuss the progress in the development of small-molecule PLK2 inhibitors. In previous our studies, pyrazolo[3,4-d]pyrimidine scaffold was selected which was synthesized through alkylation and cyclization. Some analogues were screened by protein and cell based assay. Using these results, the diversification of this compound was performed to tune the improved biological activity. This task was focused on modifying C3, C6, and N1 sites of pyrazolo[3,4-d]pyrimidine. In addition, new approach toward the synthesis of pyrazolo[3,4-d]pyrimidine analogue will be surveyed.

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