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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Controlled Physicochemical Property of PEO-b-PCL Block Copolymer Micelle mixed with Various Surfactants

2016년 2월 18일 10시 02분 48초
ANAL2.O-9 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 11분
분석화학 - 젊은 분석화학자의 구두 발표 II (Oral Presentation of Young Analytical Chemists II)
저자 및
공경현, 고혜지, 최익장, 서형림, 이영복*
한양대학교 응용화학과, Korea

Amphiphilic Polymeric micelle or emulsion has been extensively used in fields of nanomedicines and cosmetics because of its targeting delivery function. In order to make the best use of its character, it is often required to control local physicochemical properties (packing density, flexibility) of the micelle core. Dynamic property of the micelle core can be modified by mixing the micelle with an amphiphilic surfactant since the flexibility of the micelle core is solely controlled by intermolecular forces (Van der Waals force) between of them. Up to now, there have been many efforts to measure the features with mechanical or spectroscopic techniques, however, none of them were not able to investigate the characters in detail and precisely. Here, we have intensively investigated the dynamic features of PEO-b-PCL / surfactant (phospholipid and its derivatives) mixtures by NMR spectroscopy. Several NMR parameters including spin relaxation rates and diffusion coefficient are employed to determine the optimal concentration ratio between the block copolymer and a surfactant. As a result, we found that physicochemical character of the micelle is highly dependent on feature of the surfactants explained by symmetricity, number, and length of hydrophobic chains.