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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Study on the Synthesis of fully conjugated chain using chain extension unit

등록일
2016년 8월 31일 15시 39분 32초
접수번호
2246
발표코드
ORGN.P-416 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
구상호*, 김다혜
명지대학교 화학과, Korea
Carotenoids are red or yellow pigment in nature, and they are one of the important antioxidant that can prevent cancers. Carotenoids are also used as an element of cosmetics and foods. Since carotenoids cannot be sythesized in human body, they should be supplied from outsides. That is the most important reason that synthesis of carotenoids have been developed in various ways. We previously synthesized the natural carotenes by using sulfone mediated coupling reaction, protection of the resulting alcohol, double elimination. In this research, the synthesis of carotenoids was designed using benzothiazol-2-yl sulfone with crocetin dialdehyde. The Julia-Kocienski olefination enables the efficient preparation of polyenes. So chain extension of isoprenoid using Julia-Kocienski olefination efficiently provided fully conjugated carotenoid compound. The benzothiazol-2-yl sulfone containing an acetal group was prepared as an building block for the chain extension of apocarotenoids. The Julia-Kocienski olefination of the benzothiazol-2-yl sulfone containng an acetal group with 2,7-dimethyl-2,4,6-octatrienedial efficiently produced C20 crocetin dial. The C30 and C40 dials were also prepared from C20 crocetin dial by the repeated application of the Julia-Kocienski olefination of the benzothiazol-2-yl sulfone.

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