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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 pH Sensitive Fluorescent Probe for Mitochondria Imaging through ESIPT

등록일
2016년 8월 31일 16시 24분 44초
접수번호
2260
발표코드
ORGN.P-419 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
홍경임, 장우동*
연세대학교 화학과, Korea

Excited State Intramolecular Proton Transfer (ESIPT) has attracted scientists` attention because it has considerable potential, providing many applications such as molecular probes, luminescent materials, bioimaging probes etc. ESIPT molecules exhibit different fluorescent emissions depending on solvent polarity via phototautomerization. The most remarkable property of ESIPT is a large stokes shift which prevents self-absorption problem of fluorescence emission. We have synthesized a series of thiophene-based ESIPT molecules, that are oligothiophene conjugated with benzothiazole group (nT-HBT; n = 1, 2, and 3, n is number of thiophene units). 2T-HBT clearly exhibited dual emissions according to solvent polarity; green emission in non-polar solvent and blue emission in aprotic solvent. Interestingly, 2T-HBT showed clear emission enhancement at small pH value change (at pH 7~8). This effective turn-on process at the narrow pH range can be utilized as effective bio probes. Upon in vitro evaluation, 2T-HBT exhibited selective staining of mitochondrial compartment. We are going to report detailed aspect of the thiophene-based ESIPT probes.


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