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학술발표회초록보기

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Combination of photodynamic therpay and immunotherapy to overcome immunoediting-induced heterogeneity of cancer

등록일
2016년 8월 31일 17시 49분 10초
접수번호
2275
발표코드
POLY.O-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 40분
발표형식
구두발표
발표분야
고분자화학 - Oral Presentation for Young Polymer Scientists
저자 및
공동저자
임수석, 김원종1,*
POSTECH IBIO, Korea
1POSTECH 화학과, Korea
Recent tendency of cancer therapy is focused on immunotherapy as an alternative method. In spite of its strong anticancer effect, it has been reported that the immunoediting of cancer is an obstacle for successful immunotherapy. Among the pathways of immunoediting, the continuous mutation induces the heterogeneity of cancer, providing with a means of escape from attack of tumor-specific T cells. Therefore, a consecutive release of heterogeneous tumor antigens enables to retain duration of activated immune response and that would be a key factor for successful immunotherapy. Herein, we reported a nanoparticle-based system for combinatorial anticancer therapy by both photodynamic therapy (PDT) and immunotherapy (IT). First, we have fabricated a nanoparticle which can be separated into two nanoparticles under specific condition; one is for PDT and the other for IT respectively. The release of tumor proteins induced by PDT gives increasing chance for dendritic cell to uptake the proteins, presenting on its surface as a tumor-associated antigen (TAA). Moreover, an elongated retention rate of nanoparticle was observed at the tumor site and it is expected that a repetitive PDT helps tumor protein release in a consecutive way. Taken all together, the further investigation is needed to prove long-lasting anticancer immune response via the activation of dendritic cells and CD8+ T cells

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