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학술발표회초록보기

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Reactive oxygen species generated by ultrasound stimuli-responsive self-assembled nanoparticle

등록일
2016년 8월 31일 20시 13분 30초
접수번호
2291
발표코드
POLY.O-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 40분
발표형식
구두발표
발표분야
고분자화학 - Oral Presentation for Young Polymer Scientists
저자 및
공동저자
김선일, 김원종*
POSTECH 화학과, Korea
In recent years, reactive oxygen species(ROS)-mediated cancer treatment, referred to as photodynamic therapy(PDT), has emerged as a potential alternative because of its minimal invasiveness and improved site-specific action. Many groups, therefore, developed combination system of chemotherapy and photodynamic therapy. However, the non-invasive photodynamic therapy has been limited to treat superficial tumors, primarily ascribed to poor tissue penetration of light as the energy source. Ultrasound can penetrate much deeper in biological tissue because it is non-radiative and has a low tissue attenuation coefficient. The ability of ultrasound to activate some sensitizer such as porphyrin, and 5-aminolevulinic acid has led researchers to consider sonodynamic therapy (SDT) as a possible alternative to PDT. Herein, we designed a ROS stimuli-responsive self-assembled nanoparticle that can be activated by ultrasound to generate ROS. This system has potential of combination of SDT and chemotherapy for cancer treatment.

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