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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Stereoselective Synthesis of 6-Alkylidene/Benzylidene-Isoindolo[2,1-a]indoles through Pd-catalyzed 5-exo-dig cycloisomerization [우수포스터상]

등록일
2016년 9월 1일 11시 51분 50초
접수번호
2333
발표코드
ORGN.P-426 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
ALAM KHYARUL, 박진균*
부산대학교 화학과, Korea
Cycloisomerization reactions are versatile and atom-economical strategy to generate cyclic organic compounds from acyclic starting materials. For the synthesis of N-heterocyclic compounds which are highly important class of compounds found in various natural products, biologically active structures and medicinally relevant compounds, utilization of ynamides has expanded enormously.1 Isoindolo[2,1-a]indole is one of functionalized indoles that have been synthesized by employing classical synthetic organic, photochemical, radical and palladium-mediated methodologies.2 However, no reports containing alkylidene/benzylidene moieties at C-6 of the isoindolo[2,1-a]indole structure have appeared. Herein, we described Pd-catalyzed synthesis of 6-alkylidene/benzylidene-isoindolo[2,1-a]indole, which was accomplished via steroselective 5-exo-dig cycloisomerization of ortho aryl palladium species generated through C-H activation. Also, this 6-alkylidene/benzylidene-isoindolo[2,1-a]indoles can be utilized as synthetic precursor for the synthesis of highly functionalized and biologically important isoindolo[2,1-a]indoles.

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