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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Carbomylated azithromycin-incorporated zirconia hybrid monolith for enantioseparation of acidic drugs using non-aqueous capillary electrochromatography

2016년 8월 25일 15시 23분 49초
ANAL2.O-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 21분
분석화학 - Oral Presentation of Young Analytical Chemists Ⅱ
저자 및
dixitshuchi, 박정학*
영남대학교 화학과, Korea
Carbomylated derivatives of two antibiotics, namely, clindamycin phosphate (CLIP) and erythromycin (ERY) were successfully employed as co-precursors, in combination of zirconium tetrabutoxide as a precursor, to prepare chiral organic-zirconia hybrid monoliths (i.e., CLIP-ZHMs and ERY-ZHMs, respectively) via a single-step in-situ sol-gel approach in our previous works [1,2]. Their superiority over chiral organic-zirconia/silica monoliths, prepared by post-modification approach, in terms of better enantioresolution and enhanced stability inspired us to prepare ZHMs based on an another antibiotic, azithromycin (i.e., AZI-ZHMs). Monolithic columns were employed for capillary electrochromatographic enantioseparation of acidic chiral drugs in mobile phases consisting of acetonitrile (ACN) and methanol (MeOH) as organic modifiers and, acetic acid (AcOH) and triethylamine (TEA) as electrolytes. The effects of composition of mobile phase and applied voltage on chiral separation were investigated by using ketoprofen as a representative analyte. Baseline resolutions (i.e., Rs >1.5) were obtained for six acidic drugs (namely, ketoprofen, suprofen, carprofen, flurbriprofen, ibuprofen and warfarin) using a mobile phase consisting of 70/30 (v/v) ACN/MeOH with 240 mM AcOH and 20 mM TEA. The relative standard deviations for resolution values regarding column to column and batch to batch repeatability were less than 2.5% (for n=3) under optimized conditions indicating satisfactory stability of columns and reproducibility of column preparation process. [1] Dixit, S., Park, J. H., J. Chromatogr. A 2015, 1416, 129-136. [2] Tran, L. N., Dixit, S., Park, J. H., J. Chromatogr. A 2014, 1356, 289-293.