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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Three-phase direct immersion in-tube microextraction coupled with capillary electrophoresis

2016년 8월 25일 15시 30분 42초
ANAL2.O-16 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 45분
분석화학 - Oral Presentation of Young Analytical Chemists Ⅱ
저자 및
최지은, 정두수*
서울대학교 화학부, Korea
Solid phase microextraction (SPME) and liquid phase microextraction (LPME) are widely used for sample enrichment and cleanup prior to an instrumental analysis. Compared to simply applicable SPME, LPME requires more manual maneuvers. In order to overcome such shortcomings of LPME, we developed in-tube microextraction (ITME). ITME uses a liquid plug inside a capillary as an acceptor phase and thus can be in-line coupled with capillary electrophoresis (CE) with ease. Since the acceptor phase is well protected inside the capillary, ITME can be carried out under severe extraction conditions. Moreover, given that the extraction and injection processes take place simultaneously, the extraction speed and efficiency are very high. Recently we have demonstrated headspace ITME by placing a separation capillary filled with an acceptor plug in the headspace above a sample solution using a commercial CE instrument. Here, we present 3-phase direct immersion ITME coupled with CE. By immersing the separation capillary containing a basic acceptor plug and a thin organic plug into an acidic sample solution, weakly acidic analytes in the neutral form are partitioned into the organic plug, and then back-extracted into the basic acceptor plug, followed by CE. With a 3-min extraction, Ketoprofen, Ibuprofen and Naproxen were enriched 975, 1100, and 1110 times, respectively.