KCS

Solubility parameter (SP) is an important physical and chemical properties for selecting a proper solvent. Both the total solubility parameter and its constituent partial solubility parameters(Hansen solubility parameters) are widely used for the selection of appropriate solvents for given solutes. The use of the solubility parameter for the selection of solvents is based on the well-known rule of chemistry: “like dissolves like.” Thus, if the intermolecular forces between the molecules of the solvent and between the molecules of a solute are of a similar strength, the solvent is usually a good solvent for this solute. In this study, we investigated the relation between solubility parameter of extraction solvent and that of analytes for sample preparation process such as solid phase extraction(SPE) and liquid-liquid extraction(LLE). The recoveries in a given system have been correlated by the difference between solubility parameter of solvents and that of analytes. This study will help to select optimum solvent for sample preparation.