KCS

A new C₃ symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid derived chiral HPLC stationary phase (CSP 1) was reported recently and the CSP 1 showed good results in comparing with previously reported N-3,5-dintrobenzoyl(DNB) (R)-phenylglycinol derived CSP.¹ More than ten years ago, (S)-leucinol, (R)-phenylglycine and (S)-leucine derivatives were used for staring materials of 3,5-DNB based Pirkle type CSPs for chiral separation.^2,3 In this study, three C₃ symmetric CSPs(CSP 2, 3, 4) were newly prepared by the ideas and results of the three mentioned references._1~3 The synthetic procedures and applications of the new C₃ symmetric CSPs (CSP 2 ~ CSP 4) will be shown.