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A new C3 symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid derived chiral HPLC stationary phase (CSP 1) was reported recently and the CSP 1 showed good results in comparing with previously reported N-3,5-dintrobenzoyl(DNB) (R)-phenylglycinol derived CSP.1 More than ten years ago, (S)-leucinol, (R)-phenylglycine and (S)-leucine derivatives were used for staring materials of 3,5-DNB based Pirkle type CSPs for chiral separation.2,3
In this study, three C3 symmetric CSPs(CSP 2, 3, 4) were newly prepared by the ideas and results of the three mentioned references.1~3 The synthetic procedures and applications of the new C3 symmetric CSPs (CSP 2 ~ CSP 4) will be shown.
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KCS